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科研团队(中心实验室):顾勇
发布日期.[2015-02-04] 来源:  浏览:4339

姓    名:顾勇

简    介:

教授、博士生导师。1991年博士毕业于上海医科大学。1996年于日本东京医科齿科大学肾脏中心攻读博士后。现任澳门赌场网站附属华山医院肾脏科主任、上海市第五人民医院院长,中心实验室主任。国家211工程上医大肾脏科负责人、中华肾脏病学会常务委员;上海肾脏病学会副主任;中华肾脏病杂志常务编委;肾脏病与透析肾移植杂志编委;中国中西医结合肾脏病杂志编委;中国血液净化杂志编委;临床肾脏病杂志编委。

研究方向:

主要从事慢性肾脏病纤维化发病机制、维持性透析病人的并发症、黄芪肾保护机制、慢病的流行病学和社区干预、子痫前期肾损害的临床与基础等领域研究。

科研成果:

先后主持多项国家自然科学基金、国家重点基础研究发展计划(973计划)子项目、国家科技支撑计划子项目、市卫生局百人计划、国家教委211工程、上海市教委曙光计划、上海市科委学科带头人基金、教育部博士点基金等课题与研究项目。

研究生培养:  

近5年发表论文(通讯作者或第一作者):

1. Tian J, Zhang L, Zhou Y, Gu Y, et al. Angiotensin-(1-7) Attenuates Damage to Podocytes Induced by Preeclamptic Serum through MAPK Pathways[J]. Int J Mol Med. 2014.

2. Qi W, Niu J, Qin Q, Gu Y, et al. Astragaloside IV Attenuates Glycated Albumin-Induced Epithelial-To-Mesenchymal Transition by Inhibiting Oxidative Stress in Renal Proximal Tubular Cells[J]. Cell Stress Chaperones. 2014, 19(1): 105-114.

3. Qin Q, Niu J, Wang Z, Gu Y, et al. Heparanase Induced by Advanced Glycation End Products (AGEs) Promotes Macrophage  Migration Involving RAGE and PI3K/AKT Pathway[J]. Cardiovasc Diabetol. 2013, 12: 37.

4. Shi J, Xie J, He Z, et al. A Detailed Epidemiological and Clinical description of 6 Human Cases of Avian-Origin Influenza a (H7N9) Virus Infection in Shanghai[J]. PLoS One. 2013, 8(10): e77651.

5. Chen G, Zhang L, Jin X, Gu Y, et al. Effects of Angiogenic Factors, Antagonists, and Podocyte Injury On Development of Proteinuria in Preeclampsia[J]. Reprod Sci. 2013, 20(5): 579-588.

6. Xiao J, Niu J, Ye X, Gu Y, et al. Combined Biomarkers Evaluation for Diagnosing Kidney Injury in Preeclampsia[J]. Hypertens Pregnancy. 2013, 32(4): 439-449.

7. Xu C, Ding W, Zhang M, Gu Y, et al. Protective Effects of Angiotensin-(1-7) Administrated with an Angiotensin-Receptor Blocker in a Rat Model of Chronic Kidney Disease[J]. Nephrology (Carlton). 2013, 18(12): 761-769.

8. Ding W, Yang L, Zhang M, Gu Y, et al. Chronic Inhibition of Nuclear Factor Kappa B Attenuates Aldosterone/Salt-Induced  Renal Injury[J]. Life Sci. 2012, 90(15-16): 600-606.

9. Ding W, Wang F, Fang Q, Gu Y, et al. Association Between Two Genetic Polymorphisms of the Renin-Angiotensin-Aldosterone System and Diabetic Nephropathy: A Meta-Analysis[J]. Mol Biol Rep. 2012, 39(2): 1293-1303.

10. Ding W, Yang L, Zhang M, Gu Y, et al. Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress Contributes to Aldosterone-Induced Apoptosis in Tubular Epithelial Cells[J]. Biochem Biophys Res Commun. 2012, 418(3): 451-456.

11. Qin Q, Niu J, Wang Z, Gu Y, et al. Astragalus Embranaceus Extract Activates Immune Response in Macrophages Via Heparanase[J]. Molecules. 2012, 17(6): 7232-7240.

12. Qin Q, Niu J, Wang Z, Gu Y, et al. Astragalus membranaceus Inhibits Inflammation via Phospho-P38 Mitogen-Activated Protein Kinase (MAPK) and Nuclear Factor (NF)-kappaB Pathways in Advanced Glycation End Product-Stimulated Macrophages[J]. Int J Mol Sci. 2012, 13(7): 8379-8387.

13. Gu Y. [Control of Hypertension in Patients with Chronic Kidney Disease][J]. Zhonghua Nei Ke Za Zhi. 2011, 50(7): 537-538.

14. You H, Lu Y, Gui D, Gu Y, et al. Aqueous Extract of Astragali Radix Ameliorates Proteinuria in Adriamycin Nephropathy Rats through Inhibition of Oxidative Stress and Endothelial Nitric Oxide Synthase[J]. J Ethnopharmacol. 2011, 134(1): 176-182.

15. Zhang M, Chen J, Lai L, Gu Y, et al. Aldosterone Promotes Fibronectin Synthesis in Rat Mesangial Cells Via ERK1/2-stimulated Na-H+ Exchanger Isoform 1[J]. Am J Nephrol. 2010, 31(1): 75-82.

16. Yang M, Zhang M, Chen J, Gu Y, et al. Angiopoietin-1 Inhibits Mouse Glomerular Endothelial Cell Senescence Via Tie2 Receptor-Modulated ERK1/2 Signaling[J]. Am J Nephrol. 2010, 31(6): 490-500.

17. Gu Y, Niu J Y. [Mechanism of Hypertension and its Management Policies][J]. Zhonghua Nei Ke Za Zhi. 2009, 48(6): 441-442.

18. You H, Yang H, Zhu Q, Gu Y, et al. Advanced Oxidation Protein Products Induce Vascular Calcification by Promoting Osteoblastic Trans-Differentiation of Smooth Muscle Cells Via Oxidative Stress and ERK Pathway[J]. Ren Fail. 2009, 31(4): 313-319.

19. Zhang M, Chen J, Liu S, Gu Y, et al. The Role of Na+-H+ Exchanger Isoform 1 in Aldosterone-Induced Glomerulosclerosis  in Vivo[J]. Ren Fail. 2009, 31(8): 726-735.

20. Ai P, Yong G, Dingkun G, Gu Y, et al. Aqueous Extract of Astragali Radix Induces Human Natriuresis through Enhancement  of Renal Response to Atrial Natriuretic Peptide[J]. J Ethnopharmacol. 2008, 116(3): 413-421.